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异甘草酸镁抗炎作用机制研究钟才云

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甘草 酸镁抗炎 作用 机制 研究 钟才云
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异甘草酸镁抗炎作用机制研究异甘草酸镁抗炎作用机制研究 南京医科大学公共卫生学院 钟 才 云 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Alcoholic liver disease Viral infection HBV HCV Chemical liver injury Liver Liver D Diseaseiseases s Diabetes Liver cancer Liver fibrosis Drug hepatotoxicity Non alcoholic fatty liver disease Inflammation associated Liver Diseases PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Int J Mol Sci 2014 15 4 6184 223 Obesity and Liver Disease PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Alcoholic Liver Disease J Gastroenterol Hepatol 2013 28 Suppl 1 77 84 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Immunity 2014 40 1 13 24 Viral Hepatitis PRESCRIPTIVE INTEGRATIVE INTERNATIONAL J Gastroenterol Hepatol 2011 26 Suppl 1 173 9 Drug Hepatotoxicity PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Nat Rev Immunol 2014 14 3 181 94 Liver Fibrosis PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell 2000 100 1 57 70 Hallmarks of Cancer PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell 2011 144 5 646 74 Hallmarks of Cancer The Next Generation PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell 2010 140 6 883 99 Role of Inflammation in Cancer PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Clin Cancer Res 2013 19 11 2810 6 Inflammation Fibrosis and Carcinogenesis PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Int J hepatolo 2012 10 1151 1159 Reactive Oxygen and Liver Inflammation PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell 2006 124 4 823 3 Gastroenterology 2012 143 1158 1172 Origin of Inflammation PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Nat Rev Immunol 2014 14 3 181 94 Natural History of Chronic Liver Disease PRESCRIPTIVE INTEGRATIVE INTERNATIONAL J Clin Invest 2005 115 2625 2632 NF B and Inflammation PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Science 2002 298 1911 MAPK and Inflammation PRESCRIPTIVE INTEGRATIVE INTERNATIONAL PLA AA and Inflammation PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell 2010 140 6 935 50 Production and Release of IL 1 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Cell 2010 140 6 935 50 Points of Inhibition by Anti inflammatory Agents PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Nat Rev Immunol 2013 13 9 679 92 Inhibitors of MAPKs PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Inflammation 2012 35 2 560 5 Inhibitors of NF B PRESCRIPTIVE INTEGRATIVE INTERNATIONAL Expert Opin Ther Patents 2013 23 3 333 344 Inhibitors of PLA2 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 18 甘草酸单一立体异构体镁盐 一类新药 临床应用于抗炎 保护肝脏 抗炎作用机制尚待研究 Magnesium Isoglycyrrhizinate 异甘草酸镁 甘美 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制LPS诱导的炎性细胞因子水平 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制LPS诱导的NO iNOS水平 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制 LPS诱导的 cPLA2 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制花生四烯酸代谢酶水平 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制花生四烯酸代谢脂质炎症介质 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美对NF B活性的抑制作用 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美对MAPK活性的抑制作用 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL PBS DMSO PBS LPS DMSO LPS MgIG 0 5 LPS DEX10 6 LPS HYD10 4 LPS DEX10 5 LPS HYD10 3 LPS MgIG 1 LPS 免疫荧光 甘美对细胞内ROS水平的抑制作用 RAW264 7 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美对细胞内ROS水平的抑制作用 RAW264 7 流式细胞术 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美对血清中细胞因子 水平的影响 小鼠 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美对炎症模型肝脏中细胞因子和NO的影响 小鼠 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制肝脏中PLA AA介导的炎性介质 小鼠 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抑制LPS诱导的NF B 和 MAPK活性 小鼠 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美剂量依赖性地抑制由炎症刺激诱导的PLA2 AA NF B 和MAPK 关键炎性反应信号通路的活性 甘美明显降低由炎症信号调控的炎性反应酶 PLA2 COX 2 LOX iNOS 脂质炎症介质 前列腺素 血栓素 白三烯 细胞因子 IL 1 IL 6 TNF 细胞趋化因子 IL 8 等炎性因子基因与 蛋白表达水平 与糖皮质激素相比 甘美对主要炎性反应信号通路 关键分子靶标及 炎性因子基因表达的调控作用相似 然作用强度相对较弱 甘美具有明显降低细胞内ROS的作用 结论 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL 甘美抗炎作用模型 PRESCRIPTIVE INTEGRATIVE INTERNATIONAL
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